abstract：BACKGROUND AND AIMS:Atherosclerosis is a chronic lipid-driven inflammatory disease of the arterial wall. Interferon gamma (IFNγ) is an important immunomodulatory cytokine and a known pro-atherosclerotic mediator. However, cell-specific targeting of IFNγ or its signaling in atherosclerosis development has not been studi...

journal_title：Atherosclerosis

authors： Boshuizen MC,Neele AE,Gijbels MJ,van der Velden S,Hoeksema MA,Forman RA,Muller W,Van den Bossche J,de Winther MP

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Lipoprotein Lp(a) has been shown to be an independent risk factor for coronary artery disease (CAD). However, its association with CAD burden in patients with ACS is largely unknown, as well as the association of Lp(a) with lipid rich plaques prone to rupture. AIM:We aim at assessing CAD burden by coronary ...

journal_title：Atherosclerosis

authors： Niccoli G,Cin D,Scalone G,Panebianco M,Abbolito S,Cosentino N,Jacoangeli F,Refaat H,Gallo G,Salerno G,Volpe M,Crea F,De Biase L

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Carotid intima-media thickness (cIMT) is associated with CV events in adults. Thicker cIMT is found in youth with CV risk factors including obesity. Which risk factors have the most effect upon cIMT in youth and whether obesity has direct or indirect effects is not known. We used structural equation modeling...

journal_title：Atherosclerosis

authors： Gao Z,Khoury PR,McCoy CE,Shah AS,Kimball TR,Dolan LM,Urbina EM

更新日期：2016-03-01 00:00:00

abstract：:VPS10P domain receptors are a unique class of sorting receptors that direct intracellular transport of target proteins in neurons and that play central roles in neurodegenerative processes. Surprisingly, genome-wide association studies now implicate the very same receptors in cardiovascular and metabolic disturbances....

journal_title：Atherosclerosis

authors： Schmidt V,Willnow TE

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Parental history (PH) and genetic risk scores (GRSs) are separately associated with coronary heart disease (CHD), but evidence regarding their combined effects is lacking. We aimed to evaluate the joint associations and predictive ability of PH and GRSs for incident CHD. METHODS:Data for 4283 Cauca...

journal_title：Atherosclerosis

authors： Antiochos P,Marques-Vidal P,McDaid A,Waeber G,Vollenweider P

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Atherosclerosis (AS) is a chronic inflammation characterized by massive infiltration of inflammatory cells in arterial wall plaques. Programmed death ligand-1 (PD-L1), a co-stimulatory molecule, plays a vital role in regulating immune responses. We investigated the role and mechanisms of PD-L1 expressed on o...

journal_title：Atherosclerosis

authors： Chen WJ,Hu XF,Yan M,Zhang WY,Mao XB,Shu YW

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Dyslipidemia has been linked to vascular complications of Type 1 diabetes (T1DM). We investigated the prospective associations of nuclear magnetic resonance-determined lipoprotein subclass profiles (NMR-LSP) and conventional lipid profiles with carotid intima-media thickness (IMT) in T1DM. METHODS:NMR-LSP a...

journal_title：Atherosclerosis

authors： Basu A,Jenkins AJ,Zhang Y,Stoner JA,Klein RL,Lopes-Virella MF,Garvey WT,Lyons TJ,DCCT\/EDIC Research Group.

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:To compare lipid-lowering efficacy of adding alirocumab to rosuvastatin versus other treatment strategies (NCT01730053). METHODS:Patients receiving baseline rosuvastatin regimens (10 or 20 mg) were randomized to: add-on alirocumab 75 mg every-2-weeks (Q2W) (1-mL subcutaneous injection via pre-filled pen); ad...

journal_title：Atherosclerosis

authors： Farnier M,Jones P,Severance R,Averna M,Steinhagen-Thiessen E,Colhoun HM,Du Y,Hanotin C,Donahue S

更新日期：2016-01-01 00:00:00

abstract：:A soluble form of endoglin (sEng) is known to be an extracellular domain of the full-length membrane endoglin, which is elevated during various pathological conditions related to vascular endothelium. In the current review, we tried to summarize a possible role of soluble endoglin in cardiovascular pathologies, focusi...

journal_title：Atherosclerosis

authors： Rathouska J,Jezkova K,Nemeckova I,Nachtigal P

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Persons with cerebral palsy (CP) have mobility limitations and may be at increased risk for cardiovascular disease (CVD). AIMS:To determine the feasibility of assessing novel CVD risk indicators and to identify predictors of CVD risk in a clinic-based group of adults with CP. METHODS:In an observational st...

journal_title：Atherosclerosis

authors： McPhee PG,Gorter JW,Cotie LM,Timmons BW,Bentley T,MacDonald MJ

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:CVD risk increases in women after menopause. Recent data suggest higher levels of complement protein C3 and cardiovascular fat (CF) in postmenopausal women. Whether complement proteins are associated with early markers of atherosclerosis in healthy midlife women has never been evaluated. Additionally, the po...

journal_title：Atherosclerosis

authors： Nagaraj N,Matthews KA,Shields KJ,Barinas-Mitchell E,Budoff MJ,El Khoudary SR

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:Evidence has demonstrated profound influence of genetic background on cardiovascular phenotypes. Murine models in Marfan syndrome (MFS) have shown that genetic background-related variations affect thoracic aortic aneurysm formation, rupture, and lifespan of mice. MFS mice with C57Bl/6 genetic background are l...

journal_title：Atherosclerosis

authors： Dale MA,Suh MK,Zhao S,Meisinger T,Gu L,Swier VJ,Agrawal DK,Greiner TC,Carson JS,Baxter BT,Xiong W

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:The clinical utility of traditional cardiovascular (CV) risk factors to predict coronary artery disease (CAD) is insufficient and limited. Our aim was to evaluate the association between a novel ultrasound index of periarterial fat and adventitia (carotid extra-media thickness; EMT) and the severity of CAD a...

journal_title：Atherosclerosis

authors： Haberka M,Gąsior Z

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Common carotid artery intima-media thickness (CCA-IMT) is an established marker for atherosclerosis. The role of triglycerides in CCA-IMT remains controversial. We sought to determine if elevated fasting and post-challenge triglycerides are associated with CCA-IMT. METHODS:All acute ischemic stroke patients...

journal_title：Atherosclerosis

authors： Batluk J,Leonards CO,Grittner U,Lange KS,Schreiber SJ,Endres M,Ebinger M

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVE:To investigate associations of a oxidative balance score (OBS) with blood levels of total cholesterol, low-density lipoprotein- (LDL)-cholesterol, high-density lipoprotein- (HDL) cholesterol and triglycerides, and biomarkers of inflammation (serum C-reactive protein [CRP], albumin and venous total white blood...

journal_title：Atherosclerosis

authors： Lakkur S,Judd S,Bostick RM,McClellan W,Flanders WD,Stevens VL,Goodman M

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Vascular calcification is a common finding in abdominal aortic aneurysms (AAA) however whether it predicts aneurysm expansion is controversial. OBJECTIVES:1) To establish a reproducible method of assessing AAA calcification using computed tomography (CT); 2) To investigate the association between AAA calcif...

journal_title：Atherosclerosis

authors： Hendy K,Gunnarsson R,Cronin O,Golledge J

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVE:This systematic literature review sought to determine the effects of carotid atherosclerotic plaque on local arterial stiffness. METHODS:MedLine, EMBASE, and grey literature were searched with the following term: ("atherosclerosis" or "carotid atherosclerosis" or "carotid artery disease" or "carotid plaque")...

journal_title：Atherosclerosis

authors： Boesen ME,Singh D,Menon BK,Frayne R

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) have been linked with an increased risk of type 2 diabetes, but their relationships with cardiovascular disease (CVD) are uncertain. We aimed to assess the associations of ALT and AST with CVD risk and determine their potential utility for C...

journal_title：Atherosclerosis

authors： Kunutsor SK,Bakker SJ,Kootstra-Ros JE,Blokzijl H,Gansevoort RT,Dullaart RP

更新日期：2015-11-01 00:00:00

abstract：:Hypertriglyceridemia affects approximately 33% of the US population. Elevated triglyceride levels are independently associated with cardiovascular disease (CVD) risk, and severe hypertriglyceridemia is a risk factor for acute pancreatitis. Guidelines for the management of severe hypertriglyceridemia (≥5.6 mmol/L [≥500...

journal_title：Atherosclerosis

authors： Ito MK

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:Lowering low-density lipoprotein cholesterol (LDL-C) with statins reduces cardiovascular events and slows plaque progression. While this therapeutic approach has been reported to favorably modify plaque composition, this is not well characterized in humans. Also, the benefit of achieving LDL-C levels below cu...

journal_title：Atherosclerosis

authors： Kataoka Y,Hammadah M,Puri R,Duggal B,Uno K,Kapadia SR,Murat Tuzcu E,Nissen SE,Nicholls SJ

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND AND AIM:To determine the incremental diagnostic value of epicardial adipose tissue (EAT) volume in addition to the coronary artery calcium (CAC) score for detecting hemodynamic significant coronary artery disease (CAD). METHODS AND RESULTS:122 patients (mean age 61 ± 10 years, 61% male) without a previous c...

journal_title：Atherosclerosis

authors： Romijn MA,Danad I,Bakkum MJ,Stuijfzand WJ,Tulevski II,Somsen GA,Lammertsma AA,van Kuijk C,van de Ven PM,Min JK,Leipsic J,van Rossum AC,Raijmakers PG,Knaapen P

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:To compare the prevalence of lower extremity peripheral artery disease (PAD) and to assess whether age-associated progression in ankle-brachial index (ABI) differs between individuals with chronic immune-mediated inflammatory diseases (CIID) and the general population. METHODS:Pooled analysis with data from ...

journal_title：Atherosclerosis

authors： Agüero F,González-Zobl G,Baena-Díez JM,Dégano IR,Garcia-Gil M,Alzamora MT,Marrugat J,Comas-Cufí M,Pera G,Elosua R,Ramos R,Grau M

更新日期：2015-09-01 00:00:00

abstract：:Genome-wide association studies (GWASs) have identified several risk loci for coronary artery calcification. Four single-nucleotide polymorphisms (SNPs, rs1537370, rs1333049, rs2026458 and rs9349379) were associated with coronary artery calcification with P values less than 5 × 10(-8) in GWASs. It is unclear if these ...

journal_title：Atherosclerosis

authors： Zhang Y,Wang L,Zhang Z,Zhang Z,Zhou S,Cao L,Cai B,Liu K,Bai W,Xie X,Fan W,Liu X,Lu G,Xu G

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVE:The association of egg consumption with subclinical coronary atherosclerosis remains unknown. Our aim was to examine the association between egg consumption and prevalence of coronary artery calcium (CAC). METHODS:Cross-sectional study of 23,417 asymptomatic adult men and women without a history of cardiovas...

journal_title：Atherosclerosis

authors： Choi Y,Chang Y,Lee JE,Chun S,Cho J,Sung E,Suh BS,Rampal S,Zhao D,Zhang Y,Pastor-Barriuso R,Lima JA,Shin H,Ryu S,Guallar E

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Recent failures of clinical trials promoting HDL-elevating therapies have prompted research groups to focus on its functional activity in disease. Endothelial effects of HDL can be measured with in vitro cell assays. The reproducibility and biological relevance of these assays have not been explored both in ...

journal_title：Atherosclerosis

authors： O'Neill F,McLoughlin E,Riwanto M,Manz J,Adler A,Sutill E,Khan T,Haywood R,Kay CW,D'Aiuto F,Charakida M,Landmesser U,Deanfield J

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Despite its well-established prognostic value, cardiorespiratory fitness (CRF) is not incorporated routinely in risk assessment tools. Whether low CRF provides additional predictive information in asymptomatic type 2 diabetics beyond conventional risk scores and coronary artery calcification (CAC) is unclear...

journal_title：Atherosclerosis

authors： Zafrir B,Azaiza M,Gaspar T,Dobrecky-Mery I,Azencot M,Lewis BS,Rubinshtein R,Halon DA

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Psychological stress (PS) has been associated with the development of cardiovascular diseases and adverse long-term outcomes after ischemic events. However, the precise mechanisms involved are not completely understood. Here we investigated the effect of PS on ischemia-induced neovascularization, and the pot...

journal_title：Atherosclerosis

authors： Maingrette F,Dussault S,Dhahri W,Desjarlais M,Mathieu R,Turgeon J,Haddad P,Groleau J,Perez G,Rivard A

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVES:Coronary computed tomography angiography (CTA) describes several features of coronary plaques, i.e. location, severity, and composition. Integrated CTA scores are able to identify individual patterns of higher risk. We sought to test whether circulating biomarkers related with metabolism and inflammation cou...

journal_title：Atherosclerosis

authors： Caselli C,De Graaf MA,Lorenzoni V,Rovai D,Marinelli M,Del Ry S,Giannessi D,Bax JJ,Neglia D,Scholte AJ

更新日期：2015-07-01 00:00:00

abstract：:Sex differences in incidence and prevalence of and morbidity and mortality from cardiovascular disease are well documented. However, many studies examining the genetic basis for cardiovascular disease fail to consider sex as a variable in the study design, in part, because there is an inherent difficulty in studying t...

journal_title：Atherosclerosis

authors： Winham SJ,de Andrade M,Miller VM

更新日期：2015-07-01 00:00:00

abstract：UNLABELLED:An inverse, dose-dependent relationship between retrograde shear rate and brachial artery endothelial function exists in young subjects. This relationship has not been investigated in older adults, who have been related to lower endothelial function, higher resting retrograde shear rate and higher risk of ca...

journal_title：Atherosclerosis

authors： Schreuder TH,Green DJ,Hopman MT,Thijssen DH

更新日期：2015-07-01 00:00:00

abstract：:Ischaemic heart disease (IHD) is the leading cause of death in women as in men, although presentation in women is on average 7-10 years later. Recent temporal trends show declining IHD incidence and mortality among men but not among women. Other gender differences concern the prevalence of underlying mechanisms. Women...

journal_title：Atherosclerosis

authors： Crea F,Battipaglia I,Andreotti F

更新日期：2015-07-01 00:00:00

abstract：AIMS:Inhibition of the classical renin-angiotensin system (RAS) has been proved to reduce atherosclerosis. Recently, angiotensin-(1-7) [Ang-(1-7)], a new component of RAS, has been shown to attenuate atherosclerosis formation. However, direct comparison of Ang-(1-7) and angiotensin II type 1 receptor blocker (ARB) on a...

journal_title：Atherosclerosis

authors： Yang J,Sun Y,Dong M,Yang X,Meng X,Niu R,Guan J,Zhang Y,Zhang C

更新日期：2015-06-01 00:00:00

abstract：INTRODUCTION:The possible cause of accelerated atherosclerosis in NAFLD may be the relationship with the MetS and its components. Our primary goal was to evaluate the relationship between NAFLD and subclinical atherosclerosis in adult male patients between 20 and 40 years of age. Moreover, we aimed to investigate the c...

journal_title：Atherosclerosis

authors： Ozturk K,Uygun A,Guler AK,Demirci H,Ozdemir C,Cakir M,Sakin YS,Turker T,Sari S,Demirbas S,Karslıoğlu Y,Saglam M

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:In Europeans, 45 genetic risk variants for coronary artery disease (CAD) have been identified in genome-wide association studies. We constructed a genetic risk score (GRS) of these variants to estimate the effect on incidence and clinical predictability of myocardial infarction (MI) and CAD. METHODS:Genotyp...

journal_title：Atherosclerosis

authors： Krarup NT,Borglykke A,Allin KH,Sandholt CH,Justesen JM,Andersson EA,Grarup N,Jørgensen T,Pedersen O,Hansen T

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVES:To investigate the effects of estrogen on growth and smooth muscle cell (SMC)-differentiation of vascular wall-resident CD34(+) stem/progenitor cells (VRS/Pcs). METHODS AND RESULTS:The existence of CD34(+) VRS/Pcs was confirmed by immunohistochemistry in the adventitia of arteries of young (2-month-old) and...

journal_title：Atherosclerosis

authors： Wu Y,Shen Y,Kang K,Zhang Y,Ao F,Wan Y,Song J

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVE:Significant sex differences exist in cardiovascular diseases. Although an impact of gonadal hormones is presumed, it is largely unknown whether sexually dimorphic gene expression also plays a role and whether cells themselves show intrinsic sex differences. METHODS:We performed whole genome expression analys...

journal_title：Atherosclerosis

authors： Lorenz M,Koschate J,Kaufmann K,Kreye C,Mertens M,Kuebler WM,Baumann G,Gossing G,Marki A,Zakrzewicz A,Miéville C,Benn A,Horbelt D,Wratil PR,Stangl K,Stangl V

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVE:P-selectin is a cellular adhesion molecule that has been shown to be crucial in development of coronary heart disease (CHD). We sought to determine the role of P-selectin on the risk of atherosclerosis in a large multi-ethnic population. METHODS:Data from the Multi-Ethnic Study of Atherosclerosis (MESA), inc...

journal_title：Atherosclerosis

authors： Bielinski SJ,Berardi C,Decker PA,Kirsch PS,Larson NB,Pankow JS,Sale M,de Andrade M,Sicotte H,Tang W,Hanson NQ,Wassel CL,Polak JF,Tsai MY

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVE:The aim of this systematic review was to perform a meta-analysis of randomized controlled trials (RCTs) examining the efficacy of fibrate therapy in reducing plasma concentration or activity of plasminogen activator inhibitor 1 (PAI-1). METHODS:Scopus and MEDLINE databases were searched (up to October 15, 20...

journal_title：Atherosclerosis

authors： Sahebkar A,Simental-Mendía LE,Watts GF,Golledge J

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVE:To investigate the statin eligibility and the predictabilities for cardiovascular disease between AHA/ACC and ATPIII guidelines, comparing those results to concomitant coronary artery calcium scores (CACS) in a large cohort of Korean individuals who met statin-eligibility criteria. METHODS:Among 19,920 parti...

journal_title：Atherosclerosis

authors： Rhee EJ,Park SE,Oh HG,Park CY,Oh KW,Park SW,Blankstein R,Plutzky J,Lee WY

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Familial dysbetalipoproteinemia (FD), also known as type III hyperlipoproteinemia, is a genetic dyslipidemia characterized by elevated very low density lipoprotein (VLDL) and chylomicron remnant particles that confers increased risk of cardiovascular disease (CVD). The objective of this study was to evaluate...

journal_title：Atherosclerosis

authors： Koopal C,Retterstøl K,Sjouke B,Hovingh GK,Ros E,de Graaf J,Dullaart RP,Bertolini S,Visseren FL

更新日期：2015-05-01 00:00:00